“I’m not a bigot, I just hate you”
1) Madeline Wuntch hates Raymond Holt and the feeling is mutual. For so long Holt was under the misconception that she wrote a bad recommendation letter after he revealed he was gay right as she was about to sleep with him. Turns out, Holt being openly gay was one thing the regular succubus respected about him and she hated him for trying to get her kicked out of the force.
2) As explained by Dr. Daye here; he hates X-Men, not mutants. The reason is later revealed to be that X-Men never donated money to the hospital he’s operating (even though 80 percent of their patients are free healthcare receiving mutants).