Animal themed villains

Doctor Octopus - Marvel Comics

The Lizard - Marvel Comics

Vulture - Marvel Comics

Kraven The Hunter - Marvel Comics

Rhino - Marvel Comics

Chameleon - Marvel Comics

Scorpion - Marvel Comics

Unicorn - Marvel Comics

Jackal - Marvel Comics

It has to be a villain who was a human at some point in their life. So no Mayor Bellweather from Zootopia or anything like that