WTLI solo tone?

4:36

How do you get that beautiful lead tone in WTLI, specifically the outro tone of I don’t trust myself. Is it same as the rest of the WTLI stacked drive tones like Out Of My Mind and Belief. I have and American Vintage 2 strat, bluesbreaker clone, TS808 and a Boss Katana. I can hear it but it’s not there, it sounds nasally and not enough low end. Good amp settings?